The activity of these "switches" is regulated by their methylation status, chemical marks that can be added to or removed ...

Functionally, TNF-α is an important activator and product of macrophages that stimulates cytokine production in immune cells and activates fibroblasts, with subsequent tissue remodeling. 14 TNF ...

Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer cells in tumors and discovered a mechanism that accelerates tumor growth.

Cytokine storm, a life-threatening disorder involving cytokine elevations and immune-cell hyperactivation, has various causes and is characterized by constitutional symptoms, systemic inflammation, ...

Cytokines are secreted or membrane-bound proteins that regulate the growth, differentiation and activation of immune cells. The cellular alterations that give rise to cancer provoke changes in ...

The guidance confirms that assays should be undertaken using human cells to evaluate immune activation and cytokine release. The studies should also focus on key cytokines such as IL-2, IL-6, IL ...

Cell Research - Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells Skip to main content Thank you for visiting nature.com.

Researchers have developed specialized proteins that may combat the excessive immune response, known as "cytokine storms," in some severe coronavirus cases.

Inflammation, a process that was meant to defend our body from infection, has been found to contribute to a wide range of diseases, such as chronic inflammation, neurodegenerative disorders—and more ...

A team of researchers from the San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET, Milan), led by Nadia Coltella and Luigi Naldini, has unveiled a powerful strategy to rejuvenate the ...

T o fight cancer, the immune system mobilizes all its forces. 1 Innate immune cells, including macrophages, neutrophils, and monocytes, are the first recruits: They recognize cancer cells and call in ...

Immune system cells produced by a cytokine storm appear as green and red dots in a microscopic image of lung tissue infected with influenza. Photography Courtesy Hugh Rosen and Michael Oldstone, ...