What Causes Familial Hyperchylomicronemia Syndrome? FCS happens because of a mutation in certain genes related to an enzyme called lipoprotein lipase (LpL). You have to get the mutated gene from ...

The shed syndecan ectodomain can stabilize active lipoprotein lipase. These data suggest that syndecan ectodomains, shed by adipocytes in response to insulin, are physiological extracellular ...

There was an impaired ability of insulin to suppress hormone-sensitive lipase activation in white fat tissue, leading to increased lipolysis and higher plasma glycerol levels.

Access free, up-to-date clinical guidance on lipid and lipoprotein basics at Healio. We offer valuable insights for physicians.

Cold-induced activation of brown adipose tissue (BAT) has an important impact on systemic lipoprotein metabolism by accelerating the processing of circulating triglyceride-rich lipoproteins (TRL).

As an angiopoietin-like protein 3 inhibitor, Evkeeza plays a central role in lipoprotein metabolism and blocks of lipoprotein lipase and endothelial lipase. The FDA’s approval of Evkeeza was based on ...

Keywords: lipoprotein lipase (LPL), microglia, multiple sclerosis, myelination, lipid metabolism Citation: Bruce KD, Gorkhali S, Given K, Coates AM, Boyle KE, Macklin WB and Eckel RH (2018) ...

Angiopoietin-like 3 (ANGPTL3) has emerged as an important regulator of plasma lipoprotein levels by its inhibition of the enzyme lipoprotein lipase. Here, Sander Kersten provides an overview of ...

An enzyme called lipoprotein lipase is involved in a process that allows these fat molecules to be taken up by brown fat cells. However, it was not clear exactly how this process works. A protein ...

Similarly, transgenic mice with targeted overexpression of lipoprotein lipase in skeletal muscle have muscle-specific fat accumulation and muscle-specific insulin resistance. 42,43 Taken together ...

Both excess and insufficient storage of lipids in white adipose tissue are associated with dyslipidemia, insulin resistance, and an increased risk of type 2 diabetes; thus, maintaining normal ...