A key function of IRS proteins in peripheral tissues is to couple insulin receptor activation to signaling via the PI3K signal transduction pathway, and in neurons, PI3K is implicated as a key ...

If insulin can’t get out of blood vessels, it can’t act in its target tissues. “Endothelial cells are full of insulin receptors,” says Stefan Offermanns, who led the study.

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

TGHRI scientists have identified a specific insulin signaling pathway that, when activated, revs up the response of T cells in the immune system to divide rapidly and secrete cytokines, chemical ...

Analysis of individuals with rare, molecularly defined defects in the signaling pathway activated by the hormone insulin (which controls blood glucose levels), by a team of researchers at the ...

This protein blocks insulin signaling in different pathway found in fat cells and it's this mechanism that is thought to trigger the incredible lifespan-extending feature of the queen.

Ant queens typically live much longer than their workers by blocking a key part of a molecular pathway implicated in aging, a new study suggests.

Diabetes drug development gets an advance in study that shows Inceptor binds excess insulin within the beta cell and directs it towards degradation.

(Medical Xpress) -- Researchers at the Stanford University School of Medicine have identified a molecular signaling pathway that drives the growth and maturation of young human beta cells &#151 ...

The insulin signaling pathway is very well known for its function to control blood sugar levels, and its mis-regulation is a key characteristic of diabetes. And while its role in cellular wound repair ...

The researchers made the discovery while screening for genetic clues to the PI3K/Akt signaling pathway that may contribute to reduced insulin signaling. Irregularities in the PI3K/Akt pathway have ...