A key function of IRS proteins in peripheral tissues is to couple insulin receptor activation to signaling via the PI3K signal transduction pathway, and in neurons, PI3K is implicated as a key ...

If insulin can’t get out of blood vessels, it can’t act in its target tissues. “Endothelial cells are full of insulin receptors,” says Stefan Offermanns, who led the study.

Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes.

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

Protein tyrosine phosphatase receptor type J (PTPRJ) is a negative regulator of insulin signaling in neuronal cells, according to a new study, and appears to have a role in nervous system ...

Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet.

IRF1 was also found to be associated with the impairment of the insulin/IGF signaling pathway. Previous studies have linked the expression of IRF1 with male sex, older age, diabetes, and COVID-19.

In vivo assays demonstrated LINC01134 depletion hindered HCC tumor growth. Mechanism assays unveiled LINC01134 sequestered microRNA-342-3p (miR-342-3p) and recruited insulin-like growth factor 2 mRNA ...

The insulin signaling pathway is very well known for its function to control blood sugar levels, and its mis-regulation is a key characteristic of diabetes. And while its role in cellular wound repair ...

As a bridge between AD and type 2 diabetes, activation of c-Jun N-terminal kinase (JNK) pathway with the ensued serine phosphorylation of the insulin response substrate (IRS)-1/2 may be at the ...