A key function of IRS proteins in peripheral tissues is to couple insulin receptor activation to signaling via the PI3K signal transduction pathway, and in neurons, PI3K is implicated as a key ...

In the future, she says, we could harness this insulin signaling pathway to either boost the immune response to create vaccines, for example, or dampen it to heal inflammatory illnesses such as ...

When queens and wannabe queens of the species Harpegnathos saltator gear up to reproduce, a part of what’s called the insulin signaling pathway gets blocked, slowing aging, the researchers ...

(Medical Xpress) -- Researchers at the Stanford University School of Medicine have identified a molecular signaling pathway that drives the growth and maturation of young human beta cells &#151 ...

Analysis of individuals with rare, molecularly defined defects in the signaling pathway activated by the hormone insulin (which controls blood glucose levels) has provided new insight that might ...

Insulin orchestrates blood glucose levels by signaling fat and muscle cells to absorb the sugar and liver cells to stop pumping it out, so most research on insulin signaling focuses on these tissues.

A fascinating study has discovered an insulin-suppressing protein that can help extend the lifespan of some ants by 500%. It revealed that in a certain species of ant this anti-aging pathway is ...

More information: Michael Turewicz et al, Temporal phosphoproteomics reveals circuitry of phased propagation in insulin signaling, Nature Communications (2025). DOI: 10.1038/s41467-025-56335-6 ...

The insulin/IGF signaling pathway is a key pathway in the regulation of energy metabolism and cell survival. Therefore, we suspected that SARS-CoV-2 affects this signaling pathway to cause ...

Leptin and Insulin Resistance Pathway Convergence. At the cellular level, leptin signaling intersects with insulin pathways in pancreatic β-cells.

The researchers discovered that deleting the C. elegans equivalent of TRAP-alpha affects the worms' insulin signaling pathway. They went on to delete TRAP-alpha in insulin-making pancreatic beta ...