Summary A study led by Weill Cornell Medicine reveals that the APOE3-R136S mutation delays Alzheimer’s disease by inhibiting the cGAS-STING immune pathway. This mutation suppresses inflammation in ...

Heterogeneous Hippo pathway (YAP/TAZ) activation in lung adenocarcinoma drives tumor progression by enabling ferroptosis ...

The scientists showed that the mutation inhibits the cGAS-STING pathway, an innate immune signaling cascade that is abnormally activated in Alzheimer’s and other neurodegenerative diseases.

A rare gene mutation that delays Alzheimer's disease does so by damping inflammatory signaling in brain-resident immune cells, according to a preclinical study led by investigators at Weill ...

Mini Review Open access Published: 21 July 2015 Minireview Targeting LKB1 in cancer – exposing and exploiting vulnerabilities M Momcilovic & D B Shackelford British Journal of Cancer 113, 574 ...

Rationale: Mutations in the LMNA gene, encoding LMNA (lamin A/C), are responsible for laminopathies. Dilated cardiomyopathy (DCM) is a major cause of mortality and morbidity in laminopathies.

Figure 4 LBP treatment increases the Nrf2 accumulation in nucleus by activating Keap1- Nrf2∕ARE signaling pathway. (A) Immunohistochemical study of Nrf2 positive cells in kidney tissue after different ...

Oxidative stress plays a vital role in the development of cerebral ischemic/reperfusion (I/R). Targeting oxidative stress is proposed to be an effective strategy to treat cerebral I/R injury. Gentiana ...

In the process of low-temperature plasma discharge in atmospheric-pressure humid air, which involves numerous species and a myriad of reactions, the system exhibits a highly nonlinear behavior, making ...

The airway and emphysema phenotypes of chronic obstructive pulmonary disease (COPD) cluster in susceptible families. Some of this clustering is likely to be the result of shared genetic factors. There ...

Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis revealed the top 20 enriched metabolic pathways, including phenylpropanoid biosynthesis (ko00940), MAPK signaling pathway (ko4016), ...