Targeting PDHX acetylation or its downstream metabolic effects, such as lactate-driven gene expression, may offer new avenues for therapeutic intervention.

The lactate dehydrogenase (LDH) test has a wide range of uses. Learn what they are and what the results can tell you about your health.

This study aimed to analyze the LDH-specific activity in rat muscle and liver tissue, as well as lactate and glucose levels in blood plasma after intermittent hypobaric hypoxia exposure.

Ischemic stroke causes a significant worldwide health burden, with high morbidity and fatality rates. The absence of oxygen and glucose during an ischemia event triggers anaerobic metabolism, ...

Lactate dehydrogenase (LDH) stands at the intersection of pyruvate metabolism. While it is believed that inhibition of LDH redirects pyruvate to mitochondrial metabolism, suppressing glycolysis and ...

By illuminating the mechanism underlying metformin’s link to weight loss, researchers could have identified a candidate for novel weight loss pharmaceuticals. Recent research from Stanford University ...

This paper reviews the research progress of layered double hydroxide (LDH) with various types of defects and its regulation strategies in recent years. Furthermore, the relationship between the ...

Patients with paroxysmal nocturnal hemoglobinuria (PNH) had decreased quality of life (QOL) and worse fatigue that could be linked to lactate dehydrogenase levels.

Synopsis This study highlights the importance of metabolic symbiosis dependent on lactate and lactate dehydrogenase isoforms (LDHA and B) in glioblastoma development. Inhibiting both lactate ...

Background: Lactate dehydrogenase (LDH) plays an important role in cancer pathogenesis and enhanced expression/activity of this enzyme has been correlated with poor prognosis. In this study we ...

Interestingly these enzymes utilise the same active site residues to carry out this function as dehydrogenase catalysis, however esterase activity does not require the addition of the NAD (P) cofactor ...