The team found that the protein HMGB2 is uniquely expressed on the surface layer of cartilage in joints, where it supports the survival of chondrocytes, the cells that produce and maintain cartilage.

Treatment of Articular Cartilage Defects of the Knee With Autologous Chondrocyte Implantation. MedGenMed 2(2), 2000 [formerly published in Medscape Orthopaedics & Sports Medicine eJournal 4(2), 2000].

During osteoarthritis (OA), angiogenesis is increased in the synovium, osteophytes and menisci and leads to ossification in osteophytes and the deep layers of articular cartilage. Angiogenic and ...

Gene transfer technology has opened novel treatment avenues toward the treatment of damaged musculoskeletal tissues, and may be particularly beneficial to articular cartilage. There is no natural ...

Bioengineers print 3D implants with layered cells destined to become distinct combinations of tissue, like bone and cartilage. The scaffolds degrade over time to leave the natural tissues in place.

More information: Marcus Mumme et al, Clinical relevance of engineered cartilage maturation in a randomized multicenter trial for articular cartilage repair, Science Translational Medicine (2025 ...