Signal transduction is the fundamental process by which cells convert external cues into tailored intracellular responses. Through a cascade of molecular events—beginning at the cell membrane ...

This low affinity is consistent with the observation that signal transduction through TIR domains requires receptor oligomerization, induced either by ligand binding or by overexpression 7, 8, 9 ...

Eight researchers specializing in adult oncology from Fred Hutch Cancer Center and the University of Washington have been ...

Advancements in artificial intelligence (AI) are dramatically transforming the field of protein science, offering powerful ...

Fit-ligand is a computational algorithm that enables accurate modeling of multiple conformational states of ligands in X-ray crystallography and cryo-electron microscopy (cryo-EM).

Disclaimer: AlphaGalileo is not responsible for the accuracy of content posted to AlphaGalileo by contributing institutions ...

This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and ...

Meredith Whittaker remembers exactly where she was when she read the story that would spark the first major crisis of the second Trump Administration—the debacle that became known as Signal-gate ...

Oxidative stress has long been implicated in cardiovascular disease, but more recently, the role of reactive oxygen species (ROS) in normal physiological signaling has been elucidated. Signaling ...