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To further expand the knowledge concerning the NK inhibitory signal transduction via the NKG2A/CD94 receptor, we constructed the complete structure of the membrane-embedded NKG2A/CD94 receptor with ...

G-protein-coupled receptors (GPCRs) are the largest family of plasma membrane receptors, which can be activated by an external signal such as a ligand. Binding of GPCRs and ligands in the plasma ...

Vast swaths of the subway still rely on signal equipment from the Great Depression. A multibillion dollar plan, now at risk, hopes to bring the system into the 21st century ...

Cell-based screening is a promising technology for the deorphanization of ligand-receptor interactions, because multimerized ligands can enrich for cells expressing low affinity cell surface receptors ...

Signal transduction regulates the proper function of T cells in an immune response. Upon binding to its specific ligand associated with major histocompatibility complex (MHC) molecules on an antigen ...

Ligation of TNFRSF members by the corresponding TNFSF members induces signaling via dedicated signal transduction pathways (11, 14). At the same time, TNFSF ligation activates ligand-dependent signal ...

Signal transduction is the term for the process which causes chemical and physical signals to be transmitted within a cell as a series of molecular events. The most common signal transduction ...

Cyclic nucleotide-modulated channels have important roles in visual signal transduction and pacemaking. Binding of cyclic nucleotides (cAMP/cGMP) elicits diverse functional responses in different ...

G protein coupled receptors The functions of G protein in PIP2-mediated signal transduction take place in three stages: (i) identification of G proteins, (ii) comparing the detected G proteins ...