These tau knockout rats were created through transcription activator-like effector nuclease (TALEN)-mediated targeting of exon 2 of the rat Mapt gene (Ayers, Lopez et al., 2024). Tau protein was ...

Tau-associated MAPT gene increases risk for Alzheimer's disease. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2015 / 02 / 150217131120.htm ...

They mutated mice genes associated with frontotemporal dementia, specifically two lines of the MAPT gene. Subsequently, they looked at how tau hyperphosphorylation influenced pathological changes ...

(2025) The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC-derived neurons to amyloid beta and phosphorylated tau-induced neuronal dysfunction. Alzheimer's & Dementia. doi.org ...

The team’s goal was to inhibit microtubule-associated protein tau (MAPT) expression with a tau-targeting antisense oligonucleotide (ASO) called BIIB080 (/IONIS-MAPTRx).

Kathryn Bowles started her lab at the UK Dementia Research Institute at the University of Edinburgh (UK) in September 2022. Her research primarily focuses on tauopathies, with an interest in anything ...

Aquinnah Pharmaceuticals Inc. has identified new TAR DNA-binding protein 43 (TARDBP; TDP-43) aggregation and microtubule-associated protein tau (PHF-tau; MAPT) aggregation inhibitors reported to be ...