These tau knockout rats were created through transcription activator-like effector nuclease (TALEN)-mediated targeting of exon 2 of the rat Mapt gene (Ayers, Lopez et al., 2024). Tau protein was ...

"MAPT Int10+3G>A and MAPT S305N;Int10+3G>A lines show abundant hyperphosphorylated tau in the hippocampus and entorhinal cortex, but they do not develop seed-competent fibrillar structures," wrote ...

The microtubule-associated protein tau (MAPT) gene has been identified as increasing the risk for developing Alzheimer’s disease (AD), scientists report. The MAPT gene encodes the tau protein ...

The research article titled "Quantitative Chemoproteomics Reveals Dopamine's Protective Modification of Tau" has been published in Nature Chemical Biology.

Using a novel quantitative chemoproteomic strategy, the team uncovered a protective role of dopamine (DA) in regulating the function of the microtubule-associated protein Tau.

A research team at the University of Cologne has made a significant breakthrough in understanding the role of the tau protein in Alzheimer's disease.

Clinical trial results show promise for a new genetic therapy for Alzheimer’s disease that lowers levels of the tau protein known to cause the disease.

Aquinnah Pharmaceuticals Inc. has identified new TAR DNA-binding protein 43 (TARDBP; TDP-43) aggregation and microtubule-associated protein tau (PHF-tau; MAPT) aggregation inhibitors reported to be ...

Her research primarily focuses on tauopathies, with an interest in anything related to tau, the MAPT gene or the whole 17q21.31 genetic locus. At the moment, her work largely focuses on developing ...