Mitochondria provide the lion’s share of energy that cells need to function normally, so genetic defects in mitochondria can cause severe diseases that can be devastating if not caught and treated ...

For decades, the dream of fixing harmful mutations in mitochondrial DNA felt out of reach. Scientists have long known these ...

Researchers at the University of Cologne found that mitochondrial dysfunction leads to early skeletal aging by disrupting cartilage metabolism. The study identified maladaptive metabolic shifts, ...

New research published in Nature Communications into hidden mutations in mitochondrial DNA has uncovered how high mutational levels coincide with later life and link to aging markers.

Mutations accumulated in mitochondrial DNA associated with aging were earlier believed to cause aging by decreasing the energy-producing function (mitochondrial respiratory function). In this ...

More information: Qiudan Luo et al, The interaction between microglial dysfunction and mitochondrial impairment in Alzheimer's disease, Aging Research (2024). DOI: 10.26599/AGR.2023.9340020 ...

A new study explains how mitochondria act as “reservoirs” to store NAD for cells to use, which could help scientists come up with NAD-boosting therapies to combat aging and age-related diseases.