Secondary necrosis following apoptosis induction is a regulated process that is dependent on the cleavage of DFNA5 by the executioner caspase, caspase 3.

Apoptosis and necrosis seem to be regulated by different forms of caspase-8. The induction of apoptosis requires a fully processed, heterotetrameric form of caspase-8.

Necrosis and Apoptosis are crucial for multicellular homeostasis, but it also plays an ill-fated role in human disorders.

Move Over Apoptosis: Another Form of Cell Death May Occur in the Gut Though scientists don’t yet know much about it, a newly described process called erebosis might have profound implications for how ...

One promising class of agents is the proapoptotic receptor agonists. Of these, recombinant human apoptosis ligand 2/tumor necrosis factor–related apoptosis-inducing ligand (rhApo2L/TRAIL)—an optimized ...

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis of tumor cells but not most normal cells. Its roles in normal nontransformed tissues are not clear.