Fragile X disorders include two distinct conditions: fragile X syndrome (the most common single-gene cause of developmental delay and autism) and an entirely separate group of premutation syndromes.

Research led by Memorial Sloan Kettering Cancer Center (MSK) is shedding new light on how ovarian cancer evolves—insights ...

The authors proposed two hypotheses: first, that methamphetamine induces neuroinflammation, and second, that it alters neuronal stem cell differentiation. These are valuable hypotheses, and the ...

A University of Minnesota Medical School-led research team has discovered that a cancer signaling pathway has previously ...

NOTCH signaling influences these traits through interactions with other pathways like TGF-β, WNT, and hypoxia signaling.

The canonical NOTCH pathway maintains resistant cell populations, while the noncanonical pathway modulates their resistance traits.

Brain arteriovenous malformation (BAVM) is an abnormality in the cerebral vascular system. Although the upregulation of the Notch signalling pathway is a deterministic factor in BAVM, the mechanism by ...

Notch signaling, woven as it is into so many cellular pathways, is not a good target for drug therapy, but the study authors pinpointed a protein called Ebf3 that carries the Notch signal forward ...

The Notch pathway is remarkably simple without the interventions of secondary messengers. It possesses a unique receptor–ligand interaction that imparts signaling upon cleavage of the receptor ...

Introduction Notch signaling, one of the evolutionarily conserved pathways in mammals, is a central regulator of cell fate determinations through cell-to-cell interactions (Kopan and Ilagan, 2009; ...

Growing studies have shown Notch signaling pathway plays a pivotal role in the regulation of NAFLD progression. Here, we review the profile of the Notch signaling pathway, new evidence of Notch ...