A total of 71 genes, including VEGF, adrenomedullin, IL-8, decorin (associated with the hypoxia–angiogenesis–edema pathways), matrix metalloproteinase (MMP) 7, tenascin C (associated with ...

Abstract Background/aims Optic nerve tortuosity and nerve and sheath thickening are observed on MRI in some patients with neurofibromatosis type 1 (NF-1). This study aimed to determine if tortuosity ...

The FDA has accepted a new drug application for the glioma-imaging agent Pixclara, with a decision expected next year.

The prospective multicenter study observed the treatment and clinical management of children with newly diagnosed optic pathway gliomas (OPGs) associated with neurofibromatosis type 1 (NF1) to ...

High-grade gliomas are cancerous tumors that spread quickly in the brain or spinal cord. In a new study led by Mayo Clinic, researchers found invasive brain tumor margins of high-grade glioma (HGG ...

This paper presents an automatic method for the segmentation of Optic Pathway Gliomas (OPGs) from multi-spectral MRI datasets. The method starts with the automatic localization of the OPG and its core ...

We performed a phase II trial of lenalidomide in children with pilocytic astrocytomas and optic pathway gliomas who failed initial therapy. Primary objectives included determination of objective ...

Optic nerve gliomas form along the pathway of the optic nerve, which sends signals to the brain about what the eye sees. Optic nerve gliomas mostly affect kids under age 10 and those with the genetic ...

MRI with dedicated sequences is indicated to confirm diagnosis and allow disease staging. The classical Dodge staging system for OPGs classifies tumors based on anatomy with involvement of either the ...