Emerging research suggests that a daily coffee habit may contribute to longevity and improved aging. Beyond alertness, ...

New research has identified the gene Egr-1 as a critical regulator of immune balance, offering hope for autoimmune disease therapies.

Abstract Studies of human genetics and pathophysiology have implicated the regulation of autophagy in inflammation, neurodegeneration, infection, and autoimmunity. These findings have motivated the ...

A recent study published in Genes & Diseases reveals a novel role of XPR1 in promoting ovarian cancer growth by regulating ...

A recent study published in Genes & Diseases reveals a novel role of XPR1 in promoting ovarian cancer growth by regulating ...

An international team led by EPFL has discovered a powerful anti-aging pathway in roundworms, revealing how boosting the cell ...

The BAG3 protein contributes to multiple cellular functions, including cardiac contractility, protein quality control (as a co-chaperone), cardiomyocyte structural support, and regulation of autophagy ...

Autophagy is a catabolic recycling pathway triggered by various intra- or extracellular stimuli that is conserved from yeast to mammals. During autophagy, diverse cytosolic constituents are enveloped ...

An increase in the magnitude of non-selective autophagy requires regulation of the Atg1 kinase complex that involves Atg13 and Atg17. Meanwhile, the expression and turnover rate of Atg8 is elevated.

Dysfunction of the autophagy–lysosome pathway has been implicated in a variety of neurodegenerative diseases, including Alzheimer’s disease, highlighting the value of new strategies for therapeutic ...