A groundbreaking study led by Children's Hospital Los Angeles has found a novel mechanism behind neuroblastoma progression: ...

The lack of extracellular adenosine signaling in Cd73 −/− mice causes susceptibility to hypoxia-induced inflammation 24 and barrier dysfunction of the vasculature and the intestine. 25,26 The ...

Transmembrane signaling involves sensing and communicating with the extracellular environment. Part of the transmembrane signaling is a process known as autoproteolysis, which is key in different ...

This graphic illustrates paracrine adhesion signaling on small extracellular vesicles, which secretes a protein called galectin-3, which promotes endocytosis so the vesicle can be absorbed into ...

Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27502-27508. doi: 10.1073/pnas.2015919117 ...

This study reveals that neutrophil extracellular traps (NETs) drive macrophage-derived chemokine production (CXCL9/10/11) to promote CD8+ T cell ...