Structural characterization of erWalK. The sequence of the extracellular receptor of the sensor kinase WalK indicates a PAS domain known for signal detection and transduction 20.The failure of our ...

The lack of extracellular adenosine signaling in Cd73 −/− mice causes susceptibility to hypoxia-induced inflammation 24 and barrier dysfunction of the vasculature and the intestine. 25,26 The ...

A groundbreaking study led by Children's Hospital Los Angeles has found a novel mechanism behind neuroblastoma progression: ...

Transmembrane signaling involves sensing and communicating with the extracellular environment. Part of the transmembrane signaling is a process known as autoproteolysis, which is key in different ...

Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27502-27508. doi: 10.1073/pnas.2015919117 ...

This graphic illustrates paracrine adhesion signaling on small extracellular vesicles, which secretes a protein called galectin-3, which promotes endocytosis so the vesicle can be absorbed into ...

This study reveals that neutrophil extracellular traps (NETs) drive macrophage-derived chemokine production (CXCL9/10/11) to promote CD8+ T cell ...