This segment tells the story of a genetic mutation affecting the population of West Africa. Although helpful in preventing malaria, this mutation can also lead to sickle cell anemia.

These other forms of sickle-cell disease are compound heterozygous states in which the person has only one copy of the mutation that causes HbS and one copy of another abnormal haemoglobin allele.

Columnist Oluwatosin Adesoye, a doctor, sorts through the difference between sickle cell anemia and sickle cell disease — and more.

The vulnerability to severe infections is another critical challenge. The spleen, an organ vital for filtering bacteria from the blood, often becomes dysfunctional due to damage from sickle cells.

Sickle Cell Disease is an awful genetic disease that disproportionally affects black people. It's caused by a single-point mutation in DNA, which results in a modified hemoglobin protein, differing by ...

DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease ...

In sickle cell disease, red blood cells become crescent or “sickle-shaped” due to a gene mutation. These sickled red blood cells don’t move easily and can block blood flow to the rest of the ...

THE fundamental defect of sickle-cell disease is a mutation that leads to substitution of a valine for a glutamic acid residue in the beta chains of hemoglobin.1 When red cells containing the chemi ...

News Health Sickle cell anemia patient reunites with Long Island doctors whose gene therapy treatments made him symptom-free ...

Sickle cell disease is a genetic blood disorder caused by a single mutation in both copies of a gene coding for beta-globin. Beta-globin forms half of the oxygen-carrying molecule hemoglobin.

The first gene therapy treatment for sickle cell disease has been approved in the U.K. , a move that could offer relief to thousands of people with the disease.

Episode Notes Last May, a 12-year-old with sickle cell anemia was the first person to receive a new gene therapy to treat the disease.