Sickle cell disease can lead to a severe complication known as acute chest syndrome (ACS), but the underlying mechanisms are not well understood.

Discover the current pipeline candidates advancing through the clinic for the treatment of sickle cell disease.

Columnist Oluwatosin Adesoye, a doctor, sorts through the difference between sickle cell anemia and sickle cell disease — and more.

The more Betsy Adler learned about her family's medical history, the more interested and concerned she became. Several of her first cousins had been treated for cancer, and three of her male ...

The misshapen cells tend to block blood flow in the vessels, leading to frequent pain episodes, infections, and damage to organs.

DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease ...

15-year-old Jayden Wilsey's family is praying the gene therapy will ease the excruciating pain the Falmouth teen has been enduring his entire life.

Sickle cell disease is a blood disorder in which the hemoglobin is damaged and can't carry oxygen to the tissues. These blood cells with the defective hemoglobin are sticky and can build up and block ...

Though Beauzile is the first in New York to successfully undergo sickle cell anemia-curing gene therapy, he's preceded by Kendric Cromer, a 12-year-old boy from Washington, DC who received ...

Bad memory? Poor sleep habits? These inherited traits may come from your parents. But who's to blame? Here's what the science says.

Sickle cell disease is a genetic blood disorder caused by a single mutation in both copies of a gene coding for beta-globin. Beta-globin forms half of the oxygen-carrying molecule hemoglobin.