Researchers have identified that species in the gut microbiome can produce sphingolipids that protect the host from pathogens.

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Because Alk-SMase and ceramidase may generate bioactive sphingolipid metabolites from endogenous SM during fetal development, we examined the levels of key SM and ceramide species and of sphingosine.

Responsible for sphingolipid production in Pseudomonas bacteria is a specific biosynthetic gene cluster that forms the enzymes for this novel metabolic pathway. Interestingly, similar gene ...