In light of the evidence that SYK has been shown to activate mTOR in lymphoma and that mTOR has an important role in AML, we hypothesized that SYK may also regulate mTOR signaling in AML. Here, we ...

The spleen tyrosine kinase Syk has predominantly been studied in hematopoietic cells in which it is involved in immunoreceptor-mediated signaling.

Tyrosine Kinases The transduction of extracellular signals across the membrane to initiate complex cascades of molecular events regulates numerous vital cellular processes. The molecular basis of ...

Activation of TREM2 signaling evokes the DAM signature, enabling these cells to surround and engulf amyloid plaques. Researchers typically gauge such microglial activation by measuring phosphorylation ...

The cytoskeleton is a cellular scaffolding system whose functions include maintenance of cellular shape, enabling cellular migration, division, intracellular transport, signaling and membrane ...