This asymmetry resembles that of the T cell receptor, another important immune receptor whose structure was first elucidated in 2019. "It is astounding that both types of antigen receptor form ...

At the surface, the immune response to a flu virus is simple. Some cells recognize the pathogen and send a signal to the ...

Genetically engineered T cells constitute a powerful new class of therapeutic agents that offer hope for curative responses in patients with cancer. Chimeric antigen receptor (CAR) T cells were ...

Northwestern University researchers have identified structural features in engineered cell receptors that correlate with variations in receptor function.

A T cell recognizes potential targets through its T cell receptor (TCR), a plasma membrane-anchored protein which detects foreign molecules referred to as antigens presented for inspection by ...

Studies have shown that tumor-specific T cell receptors (TCRs) can be transduced into normal peripheral blood lymphocytes, which persist after transfer in about 30% of patients and effectively destroy ...

During animal development, cells divide and arrange themselves in a coordinated way, eventually forming the embryo. The cells ...

Eureka fused the binding domain of the TCRm to the γ and δ subunits of a TCR, and co-expressed a co-stimulatory molecule to create its proprietary ARTEMIS® T cell receptor.

Since T cells respond to pathogens only on direct contact with pathogen-derived antigen, they must migrate to sites where antigen is found. The T-cell receptor recognizes a peptide or lipid ...

In April, the FDA warned of risk of secondary cancers in people receiving CAR-T cell therapy. A large study now finds the risk is low and not related to the CAR-T cells.