T-cell antigen receptors composed of γ and δ polypeptide chains ... Cα contains unusual secondary structure instead of a regular outer β-sheet (Fig. 4, in green at left).

T cells are a critical part of the adaptive immune system that respond to pathogens, tumors, or play a key role in autoimmune diseases. A T cell recognizes potential targets through its T cell ...

CARs are synthetic receptors that redirect the specificity, function, and metabolism of T cells ().CARs consist of a T-cell activating domain (typically including the zeta chain of the CD3 complex ...

Eureka fused the binding domain of the TCRm to the γ and δ subunits of a TCR, and co-expressed a co-stimulatory molecule to create its proprietary ARTEMIS® T cell receptor.

This asymmetry resembles that of the T cell receptor, another important immune receptor whose structure was first elucidated in 2019. "It is astounding that both types of antigen receptor form ...

In November, the FDA announced that it was investigating the risk of secondary cancers after treatment with certain CAR-T cell therapies.. As of the end of last year, the agency had received 22 ...

Since T cells respond to pathogens only on direct contact with pathogen-derived antigen, they must migrate to sites where antigen is found. The T-cell receptor recognizes a peptide or lipid ...