Secretory progenitors accumulated αKG, exhibited reduced expression of downstream TCA-cycle enzymes, and showed elevated DNA hydroxymethylation at loci associated with secretory fate.

UAB is a stronghold at finding patients for studies, but healthy controls were harder. The Healthy Donor Cohort at the University of Alabama at Birmingham was formed last year to solve a problem — ...

Differences in TCA cycle metabolite to pyruvate ratios are due to glutamine and not glucose metabolism To date, irrespective of how the metabolomics data is analyzed, we often cannot infer ...

Clinical trials are the foundation of medical innovation, enabling life sciences companies to evaluate the safety and efficacy of new treatments. However, traditional study designs face increasing ...

As psychedelics gain traction as potential treatments for mental health disorders, an international study stands to improve the rigor and reliability of clinical research.

The world’s largest meeting on cancer research has brought promising updates on treatment and prevention for colorectal cancer, one of the deadliest types of cancers that has been rising in ...

Specifically, we examine the tricarboxylic acid cycle (also known as TCA, Krebs cycle, or citric acid cycle) and a plausible precursor prebiotic network of reactions leading to the TCA cycle.

RV‐PA coupling was negatively associated with tricarboxylic acid (TCA) cycle intermediate levels. Specifically, plasma α‐ketoglutarate and fumarate were significantly associated with all coupling ...

With the future of her cancer treatment in limbo, Natalie Phelps doesn’t know how much longer she can wait.

The fourth sublibrary combined 9 SLCs (including four transporters of TCA substrates) with 17 TCA cycle enzymes. In total, these four sublibraries tested interactions between 2286 SLC-enzyme pairs, ...

Experts emphasize the need for enhanced clinical trial infrastructure in community oncology to ensure equitable access to innovative therapies for all patients.

A groundbreaking FIFA-funded study at Kingston University will investigate whether hormonal fluctuations during menstrual cycles could be contributing to an alarming rise in career-threatening ...