Immortalization of cells is a necessary step in the development of cancer, and scientists think that the main cause is turning on an enzyme -- telomerase -- that lengthens chromosomal telomeres ...

In cancer, telomerase becomes active during telomere crisis and rescues the genomically abnormal cells by lengthening telomeres. In a series of experiments in a lymphoma mouse model, the team found: ...

Blocking telomerase kills cancer cells but provokes resistance, progression. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2012 / 02 / 120220161229.htm.

Volume 17, Issue 6, on June 5, 2025, titled “Senescence caused by telomerase inactivation in myeloid, mesenchymal, and endothelial cells has distinct effects on cancer progression.” ...

One practical application would be cancer treatment. Cancer cells have plenty of telomerase, which allows them to live and grow much longer than normal cells in our body, Chen said.

The structure of telomerase, described with the greatest detail yet, may give researchers clues to cancer treatments and other telomerase-related illnesses.

Telomerase activation or the cancer-specific, telomerase-independent alternative lengthening of telomeres (ALT) mechanism are two telomere maintenance mechanisms in human cells. Most prostate ...

But in 2008, they proved that transgenic animals for telomerase also aged more slowly and lived up to 40 percent longer if, besides expressing telomerase, they were also made more resistant to cancer.

Telomerase is often hyperactive in cancer cells, allowing them to multiply endlessly. On the flip side, insufficient telomerase activity is linked to rare genetic disorders, premature aging, and ...

Bayne, S, Liu, J-P. Hormones and growth factors regulate telomerase activity in ageing and cancer. Mol Cell Endocrinol 2005;240:11-22. Crossref. PubMed. Web of Science. Google Scholar. 95.