Here the authors show that Sae2 and Sgs1 facilitate telomere replication in telomerase-positive cells, but generate single-stranded DNA at eroded telomeres in telomerase-negative cells.

They found that in the absence of TARG1, ADP-ribose accumulated at telomeres, leading to disruption of telomere replication and premature telomere shortening.

When copying the telomere, leading-strand DNA replication should copy the CCCTAA repeats to generate the TTAGGG repeat strand, while lagging-strand synthesis should do the opposite, making new ...

Telomere dysfunction and cancer. The G-richness and highly repetitive nature of telomeric DNA pose major challenges to the DNA replication machinery. In the lab, we recently highlighted a role for the ...

Once CST–Polα/primase is onsite, the addition and removal of phosphate groups from POT1 appears to function as an on/off switch that coordinates the final steps of telomere replication.

A s DNA strands ravel and unravel in an intricate dance, one notable event takes center stage: replication. This process is essential to life, but the finer details of its orchestrated steps are still ...

Once CST-Polα/primase is onsite, the addition and removal of phosphate groups from POT1 appears to function as an on/off switch that coordinates the final steps of telomere replication.

Deregulated DNA ADP-ribosylation impairs telomere replication. Nature Structural & Molecular Biology, 2024; DOI: 10.1038/s41594-024-01279-6; Cite This Page: MLA; APA; Chicago; ...

Alternative lengthening of telomeres (ALT) cancers. ALT cancers achieve immortality by re-elongating telomeres in the G2 and M phases of the cell cycle via the break-induced replication (BIR) pathway.

Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In ...