Epigenetic modifications are key players in the regulation of fly and yeast telomeres, and recent studies indicate that the same applies in mammalian cells. These findings have implications for ...

The study found that telomere shortening, also called telomere attrition, is not a shared characteristic of all these disorders. This finding is important because it challenges the belief that ...

Since the mode of action of potential telomerase inhibitors would require that telomeres shorten before inhibition of cell proliferation is initiated, there may be a significant delay in efficacy.

We describe a novel synthetic small molecule which shows an unprecedented stabilization of the human telomeric G-quadruplex with high selectivity relative to double-stranded DNA. We report that this ...

They found significant telomere shortening only in classical Werner Syndrome, Berardinelli-Seip Congenital Lipodystrophy type 2, and Dyskeratosis Congenita.

DNA damage, telomere shortening, reactive oxygen species (ROS) overproduction, or mitochondrial dysfunction cause senescent cells to accumulate within tissues (32). There is some evidence that only 3% ...

Adults who reported weekly nightmares were more than three times as likely to die before the age of 70.

Shorter leukocyte telomere length linked to higher incidence rates of stroke, dementia, late-life depression as composite and individually.

Telomeric repeat-containing RNA is a new noncoding RNA molecule that performs various biofunctions. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an RNA-binding protein involved in the ...

This supports the hypothesis that telomere shortening is an early event in human tumor development, and that such shortening could contribute to the chromosome mutagenesis and instability that are ...