To better conduct the analysis of nucleoside analogues, hydrophilic interaction liquid chromatography–tandem mass ...

In vitro display technologies are powerful tools for isolating polypeptide binders against various target molecules. The mRNA display approach to in vitro protein selection is based upon the puromycin ...

In the biosynthesis of many macrocyclic natural products by multidomain megasynthases, a carboxy-terminal thioesterase (TE) domain is involved in cyclization and product release1,2; however, it ...

In normal marrow, dU enters the deoxyuridylate (dUMP) → thymidylate (dTMP) → DNA thymine pathway and suppresses the incorporation of subsequently added 3 HTdR (Fig. 2).15 The degree of ...

Next, by bonding to thymidylate synthetase enzyme, it inhibits synthesis of thymidine nucleotides from deoxyuridine nucleotides.

To further enhance p -cresol reduction, 4-methylphenyl phosphate synthase CreIH from Corynebacterium glutamicum ATCC 13032 was introduced. By increasing the number of cre IH genes, the recombinant ...

The solid-phase combinatorial synthesis of a new library with potential inhibitory activity against the cytoplasmic lysyl-tRNA synthetase (LysRS) isoform of Trypanosoma brucei is described. The ...