The reported cryo-EM imaging of a pentameric ligand-gated ion channel in liposomes as opposed to nanodiscs has both broad implications and contributes valuable methodological advances to the ...

Auxin is the first plant hormone—or "phytohormone"—ever identified, with its discovery dating to the late 19th and early 20th ...

1 The transmembrane-spanning α helices of the protein are separated by alternating extracellular and intracellular loops. Scientists who study GPCRs still debate how to classify them. Many researchers ...

The ECD interfacial loops are similar between the activated and desensitized structures, but the transmembrane helices show a tilting and translation away from the pore axis that is greater in the ...

(7) Transmembrane helix dimerization plays a crucial role in ... Even though a single dominant arrangement was observed for TrkB, the dimerization free energy of the helices was around half of that ...