Researchers at Karolinska Institutet have discovered a previously unknown molecule that may explain why people with type 2 diabetes often suffer from muscle weakness and muscle loss - a condition that ...

Vitamin C helps reactivate growth genes in your skin through DNA demethylation, promoting cell renewal, thickness, and a ...

Research from the University of Cincinnati reveals how the MYC oncogene alters PRPS enzymes, impacting redox homeostasis and ...

Colorectal cancer is the third most diagnosed type of cancer worldwide. Up to 80% of the cases are related to environmental ...

c-MYC controls global gene expression and regulates cell proliferation, cell differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is dysregulated in ≈70% of human ...

Figure 1. Disruption of MYC in HT29 cells. (A) The gRNA sequence and its alignment with the exon 2 of MYC. (B) Analysis of c-Myc expression in clones by western blotting. (C) Analysis of β -actin ...

The phosphorylated c-Myc then interacts with Myc-associated protein X (Max) to form a heterodimer complex. This complex then binds to the “E-box” sequence in the target gene promoter region, thereby ...

N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia Jong S Park Austin M Gabel Polina Kassir Lois Kang Prableen K Chowdhary Afia Osei-Ntansah ...

Researchers identified a new mechanism through which C-MYC may induce the proliferation and differentiation of pulmonary fibroblasts in a rodent model with idiopathic pulmonary fibrosis (IPF), as ...

The MYC oncogene family plays an important role in neoplastic disease, and has been extensively studied over decades. Evidence showing the N-terminal and C-terminal regions of MYC can function as a ...

The coding sequence of c-myc bears several non-conserved hotspot mutations which can affect the function of the produced protein. For example, myc function can be inhibited by protein p107.

Here, we show that the c-Myc/miR17-92/PTEN axis tunes PI3K activity to control the expression of RAGs in proB cells. Using different genetically engineered mouse models we show that impaired function ...