Living organisms share an ancestor called the last universal common ancestor, or LUCA. LUCA is estimated to have lived ...

Cannabis produces a complex suite of bioactive compounds, including tetrahydrocannabinol (THC) and cannabidiol (CBD), but how these molecules evolved has long been a mystery. Now, new research has ...

GROUNDBREAKING Phase 2 clinical trial data show that sorfequiline, combined with pretomanid and linezolid (SPaL), may enhance efficacy and safety in drug-sensitive tuberculosis (TB). The NC-009 trial, ...

A new study led by Rice University's Pernilla Wittung-Stafshede has revealed that protein clumps, or plaques that clog the brain, associated with Parkinson's disease are not merely waste; they can ...

This study reports a dynamic association/dissociation between malate dehydrogenase (MDH1) and citrate synthase (CIT1) in Saccharomyces cerevisiae under different ...

Current treatment options for primary aldosteronism are limited to surgery or mineralocorticoid receptor antagonists when surgery isn't an option. In a phase IIa trial, baxdrostat resolved or reduced ...

TMC207 is a first-in-class anti-TB diarylquinoline (also named R207910 or the 'J' compound) with activity against drug-sensitive and drug-resistant TB. TMC207 inhibits the proton pump of mycobacterial ...

Mineralys Therapeutics’ aldosterone synthase inhibitor has chalked up a third clinical win in recent months, demonstrating once again its potential to reduce blood pressure in patients with ...

Utilizing a filamentous fungus in the gut microbiome may provide a new strategy for treating metabolic dysfunction-associated steatohepatitis (MASH). Researchers have developed an innovative method ...

In a recent study published in Nature, researchers from the United States of America investigated how cells separate competing metabolic pathways within mitochondria, namely oxidative phosphorylation ...

In 2005, a class of compound was discovered that could inhibit the bacterium that causes tuberculosis infections in humans — Mycobacterium tuberculosis 1. Unexpectedly, the target of these drugs was ...