Work at Suzhou Genhouse Bio Co. Ltd. has led to the identification of Werner syndrome ATP-dependent helicase (WRN; RECQ3; RECQL2) inhibitors reported to be useful for the treatment of cancer.

Mitochondria are cell organelles surrounded by a double membrane. In addition to numerous essential functions in the ...

Mineralys Therapeutics’ aldosterone synthase inhibitor has chalked up a third clinical win in recent months, demonstrating once again its potential to reduce blood pressure in patients with ...

Synopsis If1 inhibition of ATP hydrolysis by the mitochondrial F0F1-ATP synthase is key to stabilize the free F1 subcomplex. If1 is crucial in mitigating mitochondrial depolarizing stress under ...

The results are a major milestone toward delivering the first targeted aldosterone synthase inhibitor treatment for uncontrolled or resistant hypertension, which could benefit millions of people ...

It is the largest phase three trial of an aldosterone synthase inhibitor for the treatment of hypertension.

The company is also investigating BJT-188, a preclinical liver-targeted fatty acid synthase (FASN) inhibitor, for the treatment of metabolic dysfunction-associated steatohepatitis (MASH).

A highly selective aldosterone synthase inhibitor, lorundrostat, showed promise for blood pressure reduction in a double-blind randomized phase IIb trial. Participants with uncontrolled and ...

To solve it, Callegari and colleagues turned to high-resolution imaging. Using human embryonic kidney cells, scientists transfected in tagged PINK1 and then treated cells with oligomycin A, an ATP ...

ATP5I stabilizes F1Fo-ATP synthase dimers, essential for cristae morphology, but its role in cancer metabolism is understudied. The research shows ATP5I interacts with a biguanide analogue, and its ...

Here, we show that inhibitory factor 1 (IF1, encoded by Atp5if1), an inhibitor of ATP synthase hydrolytic activity, is a critical negative regulator of brown adipocyte energy metabolism. In vivo, IF1 ...