P5CS-containing mitochondria lacked the MICOS complex component MIC60 and ATP synthase subunit ATP5I. Lack of OPA1 disrupted the cristae but did not prevent proline biosynthesis.

Synopsis How the hydrolytic activity of mitochondrial ATP synthase is modulated during brown adipose tissue (BAT) thermogenesis remains unexplored. This study demonstrates that reduction of inhibitory ...

As shown in Table 5, the genes encoding vital enzymes for the synthesis of hexadecanoyl-CoA and stearoyl-CoA, including acetyl-CoA carboxylase (ACACA), fatty acid synthase subunit α (FAS2), fatty acid ...

The expression of mitochondrial ATP synthase F0 subunit 8 (MT-ATP8) was significantly upregulated in NC + P compared to other groups, indicating intracellular ATP abundance for anabolic pathways.

With no known treatments for mitochondrial diseases or ATP synthase deficiency, the use of muropeptides as an ATP agonist is a significant discovery. Recent advances in the understanding of the ...

Using electron microscopy and high-speed atomic force microscopy, researchers show the internal molecular motor behind the gliding mechanism for Mycoplasma mobile to consist of two ATP synthase ...

Structural studies of a mitochondrial ATP synthase illustrate the basis for the diversity of its membrane-shaping properties.

SciLifeLab researchers Alexander Mühleip and Alexey Amunts from Stockholm University solved the structure of a mitochondrial ATP synthase with native lipids.