Obesity has reached epidemic proportions worldwide, posing a significant burden on people’s health and on healthcare systems. It is a major risk factor for ...

In the lean, healthy state, adipose tissue (AT) has critical roles in maintaining organismal homeostasis. Paramount among the various roles of AT is the regulation of whole body metabolism. While ...

Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G.A., et al. (2019) Adipose Tissue Dysfunction as Determinant of Obesity-Associated ...

Background: Thoracic aortic aneurysm (TAA) is a life-threatening disease with high morbidity and mortality rates due to fatal complications such as aortic rupture. However, molecular mechanisms ...

Disruption of circadian rhythms is a significant risk factor for cardiovascular diseases, yet the underlying mechanisms remain incompletely elucidated. BMAL1, a core component of the circadian clock, ...

Growing evidence suggests a critical role for overnutrition in the development of low-grade inflammation. Specifically, chronic inflammation in adipose tissue is considered a crucial risk factor for ...

Polycystic ovary syndrome (PCOS) is a frequent and complex condition affecting women of reproductive age and is characterized by hyperandrogenism, irregular menstrual cycles and polycystic ovarian ...