The study reveals how 6-PPDQ at environmentally relevant concentrations (0.1–10 μg/L) disrupted the citric acid cycle by reducing intermediate metabolites, including citric acid, α-ketoglutarate, ...

6-PPD quinone at environmentally relevant concentrations disrupts citric acid cycle in Caenorhabditis elegans: Role of reduction in acetyl CoA and pyruvate contents Peer-Reviewed Publication KeAi ...

The tricarboxylic acid cycle (TCA cycle, also known as the citric acid, or Krebs cycle) is considered to be one of these fundamental chemical reaction networks for aerobic organisms (and anaerobic ...

SP2509, an allosteric LSD1 inhibitor, can affect both demethylase-dependent and -independent functions of LSD1. Understanding the allosteric regulation mechanisms of SP2509 may facilitate the ...

The complete targeted profile of the organic acid intermediates of the citric acid cycle using a single stable isotope dilution analysis, sodium borodeuteride reduction and selected ion monitoring ...

Moreover, they play roles as signalling molecules, not only as allosteric regulators of many key enzymes, but also as modulators of gene expression. <br />Therefore, it is valuable to overview recent ...

Pathway analysis revealed that the citric acid cycle was the most significantly affected, with urinary excretion of citrate, cis-aconitate, isocitrate, 2-oxoglutarate and succinate reduced by 40–68%.

Recycling batteries with citric acid Highly efficient recycling process for NCM lithium-ion batteries Date: November 15, 2024 Source: Wiley Summary: A simple, highly efficient, inexpensive, and ...

The rate regulation of glycolysis is emphasized by the enzyme kinetics, including feedback regulation, feedforward activation, allosteric regulation, expression of enzymes, posttranslation ...