Massive proteomics database links gene variant APOE 4 to chronic inflammation.

Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer’s disease. Nature Neuroscience , 2021; DOI: 10.1038/s41593-021-00851-3 Cite This Page : ...

The ApoE gene may have a more influential role than first thought; ... Beta-amyloid is a sticky protein that clumps together, blocking neuron-to-neuron signaling in Alzheimer’s patients.

ApoE is an ideal target for halting progression of Alzheimer's disease, scientists say. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2012 / 12 / 121205121147.htm ...

Stress to ApoE to MHC. In this proposed model of AD, normal neurons (green) increase expression of ApoE with age or stress (purple). This drives MHC-I expression, which, in turn, could trigger tau ...

In this study, researchers looked at APOE in microglia, the brain's immune cells known to play a role in Alzheimer's disease. As the three versions of APOE are evolutionarily unique to humans ...

BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease. Neurobiol Aging. 2013 Nov;34(11):2457-64. PubMed. Ward DD, Summers MJ, Saunders NL, Janssen P, Stuart KE, Vickers ...

APOE is major Alzheimer's risk gene Peer-Reviewed Publication. WashU Medicine. image: Clumps of a damaging Alzheimer's protein (white spots ... 10.1016/j.neuron.2017.11.014. Keywords ...

People with harmful forms of the APOE gene have up to 12 times the risk of developing Alzheimer’s disease compared with those who have other variations of the gene. For years, researchers have ...

ApoE and Alzheimer's Disease -- 10 Years Later Highlights of the 9th International Conference on Alzheimer's Disease and Related Disorders; July 17-22, 2004; Philadelphia, Pennsylvania.

Alzheimer’s disease may be inherited more often than previously known, according to a new study that paints a clearer picture of a gene long known to be linked to the common form of dementia.