Immune checkpoint inhibitors have changed the future of cancer care. These powerful treatments use the body’s own immune ...

Using CD34 lineage-tracing mice and single-cell RNA sequencing, we identified a Tfh cell population derived from CD34-lineage CD4 + T cells. Untargeted and targeted metabolomics revealed distinct ...

The CD4 helper cells that could induce disease by attacking the self share an equivalent, matched population of these peacekeeper Treg cells,” Savage said. “When we removed Treg cells reactive to a ...

A team has identified a previously unknown phase of the immune response. The results challenge long-standing assumptions about the process called 'T-cell priming'. These new insights ...

During infections, the immune system needs to distinguish foreign antigens that are expressed by invading bacteria and viruses from self-antigens that are expressed by cells of the body. If not, the ...

In this report they focus on the examination of the function of the B-helper CD4 T-cell subsets T-follicular helper (Tfh) and T-peripheral helper (Tph) cells. They demonstrate that these cells are ...

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case o ...

Follicular T helper (Tfh) cells, a subset of CD4 T lymphocytes, are essential for memory B cell activation, survival, and differentiation and assist B cells in the production of antigen-specific ...

CD4+ T-cells, primarily considered to play a supportive role in the anti-tumor immune response, have now been shown to pack a punch in a mouse model of melanoma.

CD4+ T cells, or helper T cells, are one type of lymphocyte that helps coordinate the immune response against infection and disease. The cells are crucial in achieving a regulated effective immune ...

Their latest study, "Late-rising CD4 T cells resolve mouse cytomegalovirus persistent replication in the salivary gland," published in PLOS Pathogens, reveals how a subset of CD4 + "helper" T ...