The pig’s heart was graying rapidly, so McCully decided to try it. He loaded a syringe with the extracted mitochondria and ...

In the past decade, substantial evidence supports the paradigm that stem cells exert their reparative and regenerative effects, in large part, through the release of biologically active molecules ...

Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of ...

This study evaluates the effect of the secretome from porcine cardio sphere-derived cells (S-CDCs) on macrophage polarization and its downstream impact on endothelial cells (HUVECs) and cardiac ...

Mechanisms underlying targeted mitochondrial therapy for programmed cardiac cell death Fengting Jing 1 † Min Zhao 1 † Hemin Xiong 1 Xin Zeng 2 Jun Jiang 3* Tao Li 1* ...

Immune disorders are intimately involved in the pathological progression of myocardial ischemia–reperfusion injury (MIRI) and exacerbate cardiac cell damage and mitochondria-related metabolic ...

Scientists have found a novel way that includes a new lab-grown material that could help slow and even reverse some of the effects of aging in the heart.

In an article appearing June 23 in the cardiology journal Circulation, the UCSF group reports on the successful treatment of a patient with sudden and severe (acute fulminant) myocarditis using an ...

Crosstalk between splenic macrophages and cardiac fibroblasts and cell-autonomous effect of Arg-II in cardiac fibroblasts. (A) Collagen production measured as hydroxyproline content in mouse wt ...

Finally, whether and how Arg-II participates in cardiac aging and whether it is through cell-autonomous and/or paracrine effects are not known. Therefore, our current study is aimed to investigate ...

The cardiac-specific nuclear δB isoform of Ca 2+ /calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity.