If measured from beginning to end, the DNA in our cells is too long to fit into the cell's nucleus, explaining why it must be ...

In eight tumors where patients failed immune checkpoint inhibitor (ICI) treatment, Plinabulin + radiation + PD-1 inhibitors demonstrated ...

A cell-cycle checkpoint is a moment in the life cycle of a cell when, following a period of growth and DNA synthesis, a control mechanism determines whether to further grow the cell or terminate it.

Mitosis orchestrates eukaryotic cell division, maintaining genetic fidelity and playing a key role in development, tissue homeostasis, and cancer progression.

Cell cycle arrest in response to a double-stranded break is initially maintained by the DNA damage checkpoint and later by the spindle assembly checkpoint.

Defective cell cycle checkpoints as targets for anti-cancer therapies Brian Gabrielli * Kelly Brooks Sandra Pavey The University of Queensland Diamantina Institute, Princess Alexandra Hospital, ...

CDK2 inhibitors have received some attention at the 2024 ESMO Congress, with one candidate, PF-07104091, showing combination potential with CDK4-selective blockade in HR–positive, HER2–negative breast ...

Checkpoint is evaluating its lead antibody product candidate, cosibelimab, a potential differentiated anti-PD-L1 antibody licensed from the Dana-Farber Cancer Institute, as a potential new treatment ...

This Post presents the Importance of Checkpoints, their descriptions, and their significance in the cell cycle.

Ataxia-telangiectasia mutated (ATM) plays a key role in regulating the cellular response to ionizing radiation. Here,we highlight some of the new developments in the fields in our understanding of the ...

Use of Gynecologic Cancer Intergroup (GCIG) CA125 criteria to evaluate cell cycle checkpoint kinase 1 inhibitor (CHK1i) prexasertib response and disease progression (PD) in recurrent high-grade serous ...