Recent work revealed new insights into the temporal regulation of G1–S cell cycle transcription, during proliferation and in response to activation of the DNA replication checkpoint. This has ...

For example, upon leucine withdrawal, MCF10A cells complete two cell cycles and then enter a CDK2-low quiescence, whereas lysine withdrawal causes immediate cell-cycle stalling. Methionine withdrawal ...

The combined clinical cell-cycle risk (CCR) score, which includes clinical components and a molecular cell-cycle progression (CCP) component, can be used to estimate the 10-year risk of metastatic ...

If the cell cycle were like a particular score played by a molecular orchestra, E2F7 was a new conductor, guiding the same instruments in that orchestra to play a new tune, the multiciliation cycle.

Discovery within human cell cycle process to bring new understanding of cellular diseases Date: July 27, 2021 Source: University of Kent Summary: New research has uncovered an essential mechanism ...