Caspase-3 is a pivotal enzyme in the apoptosis pathway that is responsible for executing programmed cell death through the cleavage of key cellular proteins. Existing fluorescence-based probes for ...

Interim results from the phase 2 SunRISe-4 trial (NCT04919512) showed that combining the intravesical gemcitabine system TAR-200 with the PD-1 inhibitor cetrelimab provides a viable neoadjuvant option ...

Neamatallah, T., El-Shitany, N.A., Abbas, A.T., Ali, S.S. and Eid, B.G. (2018) Honey Protects against Cisplatin-Induced Hepatic and Renal Toxicity through Inhibition of NF-B-Mediated COX-2 Expression ...

Cisplatin-induced ototoxicity is associated with increased cochlear cell death resulting from DNA damage, caspase activation, oxidative stress, inflammation, and glutamate excitotoxicity. The ...

In this study, we explored the molecular mechanisms of aloe-emodin-triggered pyroptosis. Aloe-emodin inhibited proliferation and migration and triggered caspase-dependent cell death of HeLa cells in a ...

Endoplasmic Reticulum Stress-Activated PERK-eIF2α-ATF4 Signaling Pathway is Involved in the Ameliorative Effects of Ginseng Polysaccharides against Cisplatin-Induced Nephrotoxicity in Mice Xiao-meng ...

Infected mice treated with cisplatin with increased caspase-3/7 activity also had a higher [18F]-ICMT-11 PET signal compared with that of untreated infected animals.

This work suggested that celastrol could protect against cisplatin-induced acute kidney injury possibly through suppressing NF-κB and improving mitochondrial function.

Treatment with caspase-3 inhibitors blocked all these effects. Strikingly, in tau-deficient neurons, appoptosin overexpression failed to reduce surface levels of the two receptor subunits, GluR1 and ...