Interestingly, despite caspase-3 activity increase, no cleavage of PARP (a caspase-3 nuclear substrate cleaved during apoptosis) was observed and the caspase-3 inhibition with z-DEVD-fmk did not ...

Conclusions: Tumor cells identified as responsive to cisplatin by ChemoFx consistently show increased cleaved caspase-3 expression indicative of apoptosis. These results further validate the accuracy ...