Fraction, PDF, Vitamin C, Anticancer, Pancreatic Cancer, Cervical Cancer, Small-Cell Lung Cancer Share and Cite: Konno, S. , Penunuri, A. , Wong, J. , Fullerton, S. and Choudhury, M. (2025) Anticancer ...

The activated form of caspase-3 (p17 cleaved form) was present in attached, viable macrophages before exposure to oxLDL. This p17 form was also found in apparently viable as well as in TUNEL-positive ...

However, the quantifications showing increased caspase 3 in the silenced eye (done at P5) are complicated by overlap with the signal from entire dying cells in the thalamus. The authors also show that ...

To verify whether DRP1 cleavage by apoptotic caspases play a role in regulating immune responses, human DRP1-WT or caspase-resistant DRP1-3DE (a mutant of which the three D residues in the caspase ...

Claude 3 is impressive in more ways than simply acing its benchmarking tests — the LLM shocked experts with its apparent signs of awareness and self-actualization.

Since cleaved caspase-3 is the key enzyme to process GSDME into the GSDME-NT (37 kDa) fragment (Rogers et al., 2017; Wang et al., 2017), we next explored whether blocking caspase-3 activation would ...

Direct and efficient intracellular delivery of enzymes to cytosol holds tremendous therapeutic potential while remaining an unmet technical challenge. Herein, an ultrasound (US)-propelled nanomotor ...

For cleaved caspase-3 immunofluorescence we used a rabbit polyclonal antibody (Cell Signaling Technology #9661, Danvers, MA, USA) and a rabbit monoclonal antibody (R&D Systems #AF835, Minneapolis, MN, ...

Here, we show activation of caspase 3 protease limits satellite cell self-renewal, through targeted cleavage and inactivation of Pax7 in a casein kinase (CK2)-dependent manner. Temporal regulation of ...

Herein, we describe a peptide series optimized for the selective detection and inhibition of active caspase-3 in cells. These compounds exhibit low nanomolar potency against caspase-3 with >120-fold ...

Conclusions: Tumor cells identified as responsive to cisplatin by ChemoFx consistently show increased cleaved caspase-3 expression indicative of apoptosis. These results further validate the accuracy ...