To investigate the regulatory mechanisms of non-lethal function of caspase in the nervous system, we conducted comprehensive analysis of proximal proteins of executioner caspase Drice. We discovered ...

ProBio's proprietary platform utilizes an optimized single-domain antibody (sdAb) targeting CD3, overcoming these challenges by enablingthe development of highly adaptable bispecific and ...

The amount of p17 caspase-3 was reduced by in vitro blockade of FasL with an FasL-blocking antibody and was absent in macrophages from lpr/lpr mice, which lack functional Fas. Moreover, lpr/lpr ...

Apoptotic caspases, including caspase-3, -6, -7 and -8, cleave DRP1 at the motifs of D 500 FAD 503 and/or AEAD 556, suggesting that this cleavage event may occur during infection of different viruses.

Here, we used mass spectrometry to identify proteolytic substrates of caspase-3 during chick auditory brainstem development. These auditory brainstem caspase-3 substrates were enriched for proteins ...

For cleaved caspase-3 immunofluorescence we used a rabbit polyclonal antibody (Cell Signaling Technology #9661, Danvers, MA, USA) and a rabbit monoclonal antibody (R&D Systems #AF835, Minneapolis, MN, ...

Here, we show activation of caspase 3 protease limits satellite cell self-renewal, through targeted cleavage and inactivation of Pax7 in a casein kinase (CK2)-dependent manner. Temporal regulation of ...

Sequential cleavage/activation of caspase cascades are key steps in triggering apoptosis. Activated caspases, such as caspase-3, target cytoplasmic and nuclear proteins involved in maintaining ...

Following PET imaging studies, tumor tissues were excised, fixed in formalin, embedded in paraffin, sectioned (5 μm slices) and processed for active caspase-3 and DNA degradation terminal ...