Mutations disrupting the cleavage activity or p3-recognition site resulted in a defect in the nuclear entry of active caspase-3.

The anti-CC3 monoclonal antibody recognises the Asp175 residue of cleaved caspase 3 but does not discriminate between active caspase 3 and cleaved caspase-3 generated by other proteases, such as ...

Sequential cleavage/activation of caspase cascades are key steps in triggering apoptosis. Activated caspases, such as caspase-3, target cytoplasmic and nuclear proteins involved in maintaining ...

Final results from a phase I study of TRC093 (humanized anti-cleaved collagen antibody) in patients with solid cancer.