These are exciting times for biotech business Complement Therapeutics, which stands on the cusp of an important milestone in ...

An international study led by researchers at the University of Colorado Anschutz Medical Campus has identified a promising ...

The immune system has evolved to act as a first responder against infections, and scientists have revealed how it knows when to activate.

A team of scientists has uncovered how an ancient immune system, the complement system, decides when to launch an attack—revealing a hidden mathematical tipping point based on the spatial density of ...

IC-MPGN The deposits in IC-MPGN consist of parts of immune system proteins. The proteins in these deposits are both immunoglobulin (antibodies) and proteins in the complement system.

Healio: Your findings show that when granzyme K acts on the complement system, it not only drives inflammation, but also recruits immune cells and causes tissue damage. How does that occur?

This complement system has been known for about 125 years now, and over those years — over a century now — we’ve known there are three ways of activating,” Donaldo said.

For example, the nervous system can sense changes in the external environment and convey these changes through molecules and mediators with receptors in the immune system to modulate immune responses.

Through a series of experiments, they demonstrated that GZMK activated the entire complement cascade, producing complexities that drive inflammation, recruit immune cells, and cause tissue damage.

Complement protein system The complement system is a group of more than 30 proteins that are made in the liver. They are released in an inactive form to circulate through the body’s vessels and ...

This fundamental study significantly advances our understanding of how parasites evade the host complement immune system. The new cryo-EM structure of the trypanosome receptor ISG65 bound to ...

Recent clinical trials utilizing high doses of adeno-associated virus (AAV) vectors have highlighted a new challenge to AAV gene transfer—activation of the complement system. A new article in ...