A new study published in Biochemistry sheds light on how bacteria regulate their genes, challenging long-held assumptions ...

The innate immune response is the body's first line of defense against infection, and a successful immune defense takes a ...

GlobalData’s report assesses the drugs in the cAMP Specific 3',5' Cyclic Phosphodiesterase 4B pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the ...

References 1. Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013;339:786-791.

Cyclic AMP Pathway Activation Induces Intracellular Zinc Mobilization Our data suggest that, analogous to mammalian cells, the fungus C. albicans also triggers rapid intracellular zinc flux in ...

Though he did recognize that cAMP and PKA pathways have been studied for half a century, Dr. Zhong presented how his research is focused on the “spatial-temporal activity dynamics in the cyclic AMP ...

Both PTH and PTHrP act through the PTH1R to drive bone formation, increase bone mass, and lower fracture risk (Goltzman, 2018). It has been established that one mechanism for PTH-driven osteogenesis ...

The cyclic GMP-AMP (cGAMP) synthase (cGAS) recognizes cytosolic DNA and synthesizes the second messenger, cGAMP, thus activating the adaptor protein stimulator of interferon genes (STING) and ...

LOS ALTOS, Calif.-- (BUSINESS WIRE)--Alto Neuroscience today announced top-line results from a Phase 1 human brain mechanism study of a series of novel combination drugs targeting the cyclic-AMP ...

Alto Neuroscience today announced top-line results from a Phase 1 human brain mechanism study of a series of novel combination drugs targeting the cyclic-AMP pathway, a key driver of cognition, memory ...