Pleasant tactile stimulation drives social bonding in many animal species, especially mammals. Tactile stimulation forms the ...

Many people with cancer experience dramatic loss of muscle and fat tissue. In many cases, even the heart muscle is affected, which further weakens the body.

The mystery of how cancers build up resistance mechanisms and evade the treatments that should have destroyed them is a ...

The authors study how apolipoprotein L1 variants impact inflammation and lipid accumulation in macrophages. The findings will be useful for researchers investigating macrophage metabolism and ...

Interleukin-2 (IL-2) inhibitors are immunosuppressive agents that block the activity of IL-2, a cytokine involved in the activation and proliferation ...

Thymagen peptide is characterized by a specific sequence of amino acids that may allow it to engage with intracellular pathways. Research indicates that the peptide might exhibit regulatory potential ...

Mechanism studies indicated that the degradation ability of these SRC-3 PROTAC degraders is ubiquitin proteasome system (UPS) pathway-dependent. Moreover, BY13 displays a highly selective blocking ...

Here, we identified an alternative signaling pathway that cGAS engages independent of cGAMP synthesis. We demonstrate that alternative cGAS signaling promotes hyperexpression of CXCL1 and enhanced ...

During differentiation, cytokine signaling ensures lineage specificity by mimicking embryonic development pathways. For instance, Activin A and BMP2 guide the development of endodermal tissues, such ...

Discover how cytokines are influencing stem cell and organoid research, paving the way for breakthroughs in drug discovery.

Given that animals lacking this gut cytokine-to-glial signaling fail to maintain a high sleep state during oxidative stress, instead exhibiting increased wakefulness, this pathway appears to suppress ...